Voriconazole Powder Cas No.137234-62-9
Khoom Source: Synthetic
Specification: Ntau dua lossis sib npaug li 98%
CAS Nr .: 137234-62-9
Molecular Formula: C₁₆H₁₄F₃N₅O
Molecular Luj: 349.31
Test Method: HPLC
Cov khoom xyaw nquag: Voriconazole
Cov yam ntxwv ntawm cov khoom: Dawb rau greyish -dawb crystalline hmoov
Ntim Cov Khoom: 1kg / hnab; 25kg / nruas
Cia Lub Sijhawm: Khaws ntawm chav tsev kub kom deb ntawm lub teeb
Lub neej txee: 24 lub hlis
Kev Tshaj Tawm Txog Kev Siv: Cov khoom no yog tsim los siv rau kev lag luam lossis kev tshawb fawb tshawb fawb nkaus xwb.
Khoom Description
Xi'an Tihealth Siab -Specification Voriconazole API
Peb lub siab -purity Voriconazole API (Voriconazole Powder) yog tsim nyob rau hauv nruj raws li cov qauv cGMP. Cov khoom purity tsis tu ncua ntau tshaj 98% thiab ua raws li HPLC kev tswj xyuas kom zoo, ua kom muaj cov khoom tshwj xeeb - mus rau -batch sib xws thiab kev ntseeg tau.
Synthesized siv cov thev naus laus zis siab heev, cov khoom lag luam no muaj cov qib impurity tsawg thiab siab solubility (txog 50 mg / mL hauv DMSO), ua raws li cov kev cai thoob ntiaj teb pharmacopoeia xws li USP thiab EP. Xi'an Tihealth yog koj tus khub ntseeg siab rau siab - cov khoom siv tshuaj zoo.
Cov khoom muaj nuj nqi
Voriconazole yog ib qho dav -spectrum, thib peb- tiam hluavtaws triazole antifungal tus neeg sawv cev. Nws cov txheej txheem tseem ceeb cuam tshuam nrog inhibiting ergosterol biosynthesis nyob rau hauv fungal cell membranes, cuam tshuam cov membrane kev ncaj ncees thiab kev ua haujlwm, yog li ua rau fungal cell tuag lossis kev loj hlob inhibition.
Cov khoom Apdaim ntawv thov
Voriconazole feem ntau yog qhia rau kev kho cov kab mob loj hauv qab no, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob immunocompromised (xws li, cov neeg tau txais kev hloov pauv hauv nruab nrog cev, kws khomob-induced neutropenia, HIV/AIDS):
1). Invasive Aspergillosis:Tshwj xeeb tshaj yog pulmonary aspergillosis, uas yog nws cov thawj qhia.
2). Candidiasis:Xws li cov kab mob candidemia thiab cov kab mob loj heev tshwm sim los ntawm fluconazole-cov kab mob resistant Candida (xws li Candida krusei).
3). Lwm yam kab mob uas tsis tshua muaj tab sis hnyav fungal:tshwm sim los ntawm Fusarium spp., Scedosporium spp., thiab lwm yam.
4). Lwm yam kab mob fungal:Kuj tseem siv tau los kho cryptococcosis (xws li, cryptococcal meningitis), coccidioidomycosis, histoplasmosis, thiab penicilliosis.
Mechanism ntawm Akev txiav txim
Lub mechanism ntawm kev txiav txim ntawm voriconazole yog raws li nram no:
1). Inhibition ntawm cov haujlwm tseem ceeb enzyme: Nws cov khoom xyaw nquag muaj tshwj xeeb inhibits fungal cytochrome P450-dependent 14 -lanosterol demethylase. Qhov no enzyme yog ib qho tseem ceeb enzyme nyob rau hauv ergosterol biosynthesis txoj kev.
2). Kev cuam tshuam ntawm cell membrane synthesis: Inhibition ntawm no enzyme impairs lub synthesis ntawm precursors rau ergosterol (thawj sterol tivthaiv ntawm fungal cell membranes) thaum ua rau cov tsub zuj zuj ntawm lom methylated sterol intermediates nyob rau hauv cov kab mob fungal.
3). Induction ntawm cell tuag: Qhov tsis muaj ergosterol thiab tsub zuj zuj ntawm cov tshuaj lom intermediates cuam tshuam cov qauv thiab kev ua haujlwm ntawm fungal cell membranes, nce membrane permeability thiab thaum kawg ua rau fungal cell loj hlob inhibition lossis tuag.
Mechanism of Action Schematic Diagram
Cim npe nrov: voriconazole hmoov cas no.137234-62-9, Tuam Tshoj voriconazole hmoov cas no.137234-62-9 manufacturers, lwm tus neeg, Hoobkas
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