Teduglutide hmoov CAS No.197922-42-2
Cov khoom lag luam: Nws yog glucagon zoo li peptide-2 (GLP-2) analog
Cov ntsiab lus tshwj xeeb: Ntau dua lossis sib npaug li 98%
CAS Nr .: 197922-42-2
Cov tshuaj formula yog C164H252N44O55S
Molecular Luj: 3752.08
Txoj kev kuaj pom: HPLC
Cov khoom xyaw nquag: Teduglutide
Cov lus piav qhia ntawm cov khoom: Dawb kom tawm dawb khov - cov hmoov qhuav
Khoom siv: kev tshawb fawb tshawb fawb thiab kev sim tshuaj pharmacological, nrog rau kev mob plab hnyuv luv
Cov khoom ntim: 1 gram / lub raj mis; 10 fwj / lub thawv (customizable)
Cov khoom cia: Nws raug nquahu kom khaws cia khov ntawm -15℃txog -20℃thiab tsis txhob tshav ntuj ncaj qha
Lub neej txee: 24 lub hlis
Khoom Description
Teduglutide muab los ntawm Xi'an Tinoj qab haus huv
Peb siv peb tus kheej cov kab ntau lawm uas ua tau raws li cov qauv thoob ntiaj teb los tsim cov khoom siv siab -purity raw khoom tshwj xeeb rau kev tshawb fawb tshuaj thiab kev siv tshuaj kho mob. Ua raws li cov txheej txheem tswj impurity thiab ua raws li Suav Pharmacopoeia thiab thoob ntiaj teb kws tshuaj raw khoom specifications. Muaj zog batch stability, residual noo noo tsawg dua los yog sib npaug rau 1.0%, endotoxin tswj nyob rau hauv tsawg tshaj li los yog sib npaug zos rau 5EU / mg, kom muaj kev ruaj ntseg ntawm kev siv ncaj qha nyob rau hauv formulation ntau lawm.
Cov khoom no tau raug kuaj xyuas tau zoo los txhim kho txoj hnyuv plab zom mov thiab pab cov neeg mob txo lawv txoj kev vam khom rau cov khoom noj khoom haus parenteral. Peb muab customized ntim xws li los ntawm 1g rau kg los pab cov neeg muas zaub nyob rau hauv kev ua tau zoo nce qib tshuaj tshawb fawb thiab ntau lawm.
Cov khoomMuaj nuj nqi
Tedroside txhim kho txoj hnyuv ua haujlwm los ntawm kev ua raws li qhov kev txiav txim ntawm ntuj GLP-2 thiab feem ntau yog siv rau kev kho mob ntawm plab plob tsis so tswj (SBS).
Lub luag haujlwm tseem ceeb:
Txhawb txoj hnyuv nqus, txo qhov kev cia siab ntawm parenteral khoom noj khoom haus, thiab txhim kho plab hnyuv muaj nuj nqi
Cov khoomAppdaim ntawv qhia
Cov lus qhia:Short bowel syndrome nyob rau hauv cov neeg laus thiab cov me nyuam
Clinical effect:Tom qab 24 lub lis piam ntawm kev kho mob, 63% ntawm cov neeg laus cov neeg mob tau pom qhov txo qis ntawm cov khoom noj khoom haus sab nraud, thaum cov neeg mob uas tseem tshuav tau thim rov qab.
Mechanism ntawmAkev txiav txim
Tedroside siv cov teebmeem hauv qab no los ntawm kev khi rau GLP-2 receptors hauv txoj hnyuv:
Txhawb txoj hnyuv loj:txhawb kev loj hlob ntawm crypt hlwb thiab nce qhov nqus ntawm qhov chaw ntawm txoj hnyuv.
Tso cov khoom loj hlob xws li insulin{{0}zoo li kev loj hlob zoo (IGF-1):keratinocyte kev loj hlob zoo (KGF), thiab nitric oxide, uas tuaj yeem kho lub plab hnyuv epithelial barrier thiab txhim kho cov as-ham.
Inhibit gastric acid secretion:txo lub plab khoob, yog li txhim kho txoj hnyuv ua haujlwm
Cim npe nrov: Tuam Tshoj teduglutide hmoov cas no.197922-42-2 manufacturers, lwm tus neeg, Hoobkas
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