Atosiban Acetate Cas No. 914453-95-5
Cov khoom siv: Chemical synthesis
Cov ntsiab lus ntawm cov khoom: Ntau dua lossis sib npaug li 98%
CAS Nr .: 914453-95-5
Txoj kev kuaj pom: HPLC
Cov khoom xyaw nquag: cyclic nonapeptide
Cov mis mos molecular: C45H71N11O14S2
Molecular Luj: 1054.25
Cov lus piav qhia: Dawb rau tawm dawb crystalline hmoov, yooj yim soluble hauv dej
Khoom siv: kev tshawb fawb tshawb fawb, kws tshuaj
Cov khoom ntim: 1 mg -10 g; Yeem 1g lub raj mis, 10g lub raj mis, 50g lub raj mis, thiab lwm yam
Cov khoom cia: -20 degree, kaw hauv qhov tsaus ntuj (qhuav); Cov lus qhia ib nrab: Cov tub yees ntawm 2-8 degree
Lub neej txee: 24 lub hlis
Khoom Description
Xi'an Tihealth Atosiban Acetate Khoom Txheej txheem cej luam
Xi'an Tihealthtsom rau siab -cov tshuaj qib peptide raw khoom zoo. Atosiban acetate (CAS 90779-69-4 / acetic acid daim ntawv 914453-95-5) ua nruj me ntsis raws li kev tswj hwm qhov system muaj purity zoo thiab ruaj khov. Cov khoom no siv cov txheej txheem sib xyaw ua ke thiab kev ua kom huv huv, thiab qhov purity ntawm cov khoom siv sib xyaw tuaj yeem raug txheeb xyuas los ntawm HPLC kom dhau 98%. Nws kuj tseem tuaj yeem muab cov khoom lag luam tshwj xeeb nrog cov purity ntau dua lossis sib npaug li 99%, ua tau raws li qhov xav tau nruj ntawm kev tshawb fawb tshuaj thiab kev tsim khoom. Cov khoom lag luam yog cov dawb dawb dawb crystalline hmoov nrog cov dej solubility zoo heev (Ntau dua lossis sib npaug ntawm 50 mg / mL) thiab siab sib xws ntawm cov khoom siv, kom ntseeg tau tias muaj kev txhim kho txhim khu kev qha ntawm cov qauv kev sim lossis ntau lawm.
Xi'an TihealthBiotechnology Co., Ltd. tau cog lus los muab cov neeg siv khoom ruaj khov, ua raws, thiab txhim khu kev qha siab - zoo acetic acid atosiban raw cov ntaub ntawv. Peb yog koj tus khub zoo los ntawm kev tshawb fawb thiab kev loj hlob mus rau ntau lawm
Cov khoomMuaj nuj nqi
Atosiban acetate yog ib qho kev xaiv uterine contraction inhibitor uas muaj kev sib tw antagonizes oxytocin receptor (OXTR) thiab vasopressin V1A receptor (V1AR) ntawm uterine du nqaij, thaiv cov oxytocin thiab vasopressin mediated uterine contraction signaling pathway thiab inhibiting uterine contractions. Nws cov haujlwm tseem ceeb suav nrog:
1. Ceev inhibition ntawm uterine contractions:Kev txo qis hauv uterine contraction zaus thiab kev siv tsis pub dhau 10 feeb tom qab txhaj tshuaj.
2. Tuav lub uterine Stillness:ncua lub sij hawm cev xeeb tub thiab muab lub sij hawm tseem ceeb ntawm lub qhov rais rau kev txhawb nqa kev kho mob ntawm tus menyuam hauv plab
Cov khoomKev thov
1. Cov lus qhia kho mob
Haum rau cov poj niam cev xeeb tub ntawm 24-33 lub lis piam ntawm cev xeeb tub uas ua tau raws li cov xwm txheej hauv qab no, ncua kev yug ntxov ntxov ntxov, raws li qhia hauv qab no
Uterine contraction indicators, uterine contraction status, soj ntsuam fetal
2. Cov xwm txheej tshwj xeeb ntawm daim ntawv thov
Assisted reproductive technology (ART), lwm txoj rau cov tshuaj uterine contraction inhibitors
Mechanism ntawm kev ua
1. Receptor qib antagonism
Lub hom phiaj khi:Kev sib tw sib tw ntawm OXTR thiab V1AR hauv cov leeg nqaij uterine, decidua, thiab daim nyias nyias, thaiv cov teebmeem ntawm endogenous oxytocin thiab vasopressin.
Teeb liab txoj kev inhibition:
● Inhibiting Gq protein conjugation → txo inositol triphosphate (IP3) ntau lawm → thaiv sarcoplasmic reticulum calcium ion tso tawm;
● Inhibition ntawm voltage-gated calcium channel qhib → txo cov calcium ntxiv
2. Uterine tej teebmeem
Cov nqaij ntshiv du, prostaglandin inhibition
Toxicological xaus
● Lub sij hawm toxicity:
Cov dev / nas tau txhaj tshuaj 10 zaug ntawm tib neeg koob tshuaj rau 3 lub hlis, thiab tsis pom muaj kev puas tsuaj rau hauv nruab nrog cev.
● Kev tsim tawm toxicity:
Kev kis tus menyuam yaj hauv plab tsis ua rau muaj qhov tsis zoo; Tsis muaj pov thawj ntawm kev hloov pauv caj ces lossis carcinogenicity (Ames test / chromosomal aberration test negative)
Cov ntsiab lus tseem ceeb
Acetate atosiban, raws li uterine tshwj xeeb uterine contraction inhibitor, ua tiav kev xa menyuam ntxov ntxov los ntawm cov txheej txheem receptor antagonism meej. Nws txoj kev nyab xeeb ntawm cov hlab plawv yog qhov zoo dua li cov tshuaj ib txwm siv, thiab tsis muaj qhov tseeb ntawm fetus toxicity. Kev nruj me ntsis raws li cov lus qhia thiab kev noj tshuaj yog qhov tseem ceeb ua ntej kom ntseeg tau tias muaj txiaj ntsig zoo.
Cim npe nrov: Tuam Tshoj atosiban acetate cas no. 914453-95-5 manufacturers, lwm tus neeg, Hoobkas
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