Baloxavir Marboxil Powder CAS NO.1985605-59-1
CAS Nr .: 1985605-59-1
Txoj kev kuaj pom: HPLC
Cov khoom xyaw nquag: Baloxavir marboxil
Cov lus piav qhia: Dawb rau tawm dawb crystalline hmoov
Khoom siv: Tshuaj tiv thaiv kab mob khaub thuas
Cov khoom ntim: 1mg / lub raj mis; 10 fwj / thawv
Cov khoom cia: kaw, deb ntawm lub teeb, qhuav thiab khaws cia ntawm chav tsev kub ntawm 20-25 degree, tsis khov
Lub neej txee: 24 lub hlis
Khoom Description
Bivalirudin nrog siab purity los ntawm Tihealth
Peb qhov kev tsim khoom ntawm Bivalirudin tsom rau kev ua haujlwm siab, siab zoo, thiab cov ntsiab lus siab, nruj me ntsis raws li cov kws tshuaj thoob ntiaj teb (USP / NF, EP, ChP) thiab GMP cov qauv. Lub purity tau raug txheeb xyuas los ntawm HPLC thiab huab hwm coj spectrometry, thiab tag nrho cov ntsiab lus impurity tsawg dua 0.1%.
Cov khoom no yog tsim tshwj xeeb rau kev kho plawv plawv (PCI) thiab mob plawv mob plawv (ACS), ncaj qha inhibiting thrombin yam tsis muaj kev vam khom rau antithrombin III, txo qhov kev pheej hmoo ntawm los ntshav (tshwj xeeb tshaj yog intracranial hemorrhage), txo lub sijhawm rov qab los, thiab zam kev pheej hmoo ntawm heparinbocytopenia.
Raws li kev soj ntsuam kuaj mob, nws muaj kev nyab xeeb dua li cov txheej txheem hauv kev phais mob plawv, thiab tsis tas yuav tsum tau saib xyuas kev ua haujlwm ntawm coagulation, ua tau raws li cov txheej txheem siab ntawm cov tuam txhab tshuaj, cov tsev kho mob, thiab CRO tuam txhab. Nws muab cov khoom ruaj khov zoo thiab cov kev daws teeb meem, thiab pab nrog cov kev coj ua anticoagulation meej hauv kev kho mob plawv.
Cov khoom muaj nuj nqi
1. Ua kom luv luv ntawm cov kab mob khaub thuas: Cov kev sim tshuaj tau pom tias nws tuaj yeem txo qhov ntev ntawm cov tsos mob khaub thuas (xws li ua npaws, hnoos, qaug zog, thiab lwm yam), nrog qhov txo qis ntawm 1 hnub.
2. Txo cov kab mob kis tau yooj yim: ceev ceev inhibit influenza virus replication thiab qis nasopharyngeal viral load.
3. Txo qhov kev pheej hmoo ntawm cov teeb meem: yuav txo qis qhov tshwm sim ntawm cov teeb meem loj xws li mob npaws ntsig txog mob ntsws.
Iua tsaug rau:
Cov neeg mob khaub thuas muaj hnub nyoog 12 xyoos thiab siab dua (cov txiaj ntsig zoo tshaj plaws tau ua tiav hauv 48 teev ntawm qhov tshwm sim tshwm sim).
Ob tus kab mob khaub thuas A thiab B tau siv tau.
Mechanism ntawm kev ua
1. Lub Hom Phiaj:
Influenza virus RNA polymerase (CAP dependent endonuclease).
Cov enzyme no yog cov protein tseem ceeb rau cov kab mob sib kis, lub luag haujlwm rau "hijacking" tus tswv tsev cell RNA txhawb nqa los tsim cov kab mob RNA.
2. Txheej txheem ntawm kev ua:
Prodrug activation: Tom qab kev tswj hwm qhov ncauj, nws tau hloov mus rau hauv cov tshuaj metabolite Baloxavir hauv lub cev.
Inhibition of viral replication: Balosevir khi rau tus kab mob RNA polymerase, thaiv nws txoj haujlwm ntawm "txiav" tus tswv tsev cell RNA txhawb nqa.
Inhibit the synthesis of viral mRNA, yog li tiv thaiv kab mob genome replication.
3. Qhov txawv ntawm cov tshuaj ib txwm:
Tsis zoo li oseltamivir (ib qho tshuaj neuraminidase inhibitor), nws yog ib qho kev ua haujlwm tshiab.
Cov Khoom Siv
1. Kev kho mob khaub thuas: Siv rau kev kho tshuaj tiv thaiv kab mob thaum ntxov ntawm cov tsos mob (hauv 48 teev), tshwj xeeb tshaj yog rau cov neeg mob uas tsis tuaj yeem tiv taus oseltamivir.
2: Muaj peev xwm txuas ntxiv siv:
Kev Tiv Thaiv Kev Kho Mob: Kawm thiab tshawb nrhiav nws daim ntawv thov hauv kev tiv thaiv kab mob khaub thuas tom qab kis mob khaub thuas (yuav tsum muaj ntaub ntawv kho mob ntau ntxiv).
Cov pab pawg muaj kev pheej hmoo siab: xws li cov neeg laus, cov neeg mob uas muaj kab mob ntev, thiab cov uas muaj feem yuav mob khaub thuas (yuav tsum tau soj ntsuam los ntawm kws kho mob).
Khoom zoo
1. Kev tswj hwm qhov ncauj ib zaug
2. Kev pib sai
3. Muaj peev xwm tiv thaiv yeeb tshuaj
4. Kev nyab xeeb zoo
Cov khoom sib piv
|
Yam ntxwv |
Mabaloxavir |
Oseltamivir |
|
Mechanism ntawm kev ua |
Inhibition ntawm RNA polymerase (CAP dependent) |
Inhibition ntawm neuraminidase |
|
Txoj kev tshuaj |
Ib koob tshuaj rau qhov ncauj (20-40mg) |
Ob zaug ib hnub rau 5 hnub sib law liag (75mg / zaug) |
|
Siv tau ceev |
Kev txo qis hauv viral load hauv 24 teev |
Siv tau hauv 48 teev |
|
Tshuaj tiv thaiv |
Cov tshuaj tiv thaiv kab mob oseltamivir resistant |
Qee hom kab mob no tiv taus |
|
Ua raws |
High (ib koob tshuaj) |
Nruab nrab (yuav tsum tau ntau koob) |
Cov ntsiab lus:
Baloxavir Marboxil Powder yog ib qho tshuaj tiv thaiv kab mob hauv qhov ncauj tshiab rau kev kho mob khaub thuas. Nrog nws ib zaug - koob tshuaj, qhov pib sai thiab cov txheej txheem tshwj xeeb ntawm kev ua, nws tau ua kom muaj kev vam meej hauv kev kho mob khaub thuas. Nws qhov zoo nyob hauv kev ua kom yooj yim ntawm cov txheej txheem tshuaj, txo qhov kev pheej hmoo ntawm kev tiv thaiv tshuaj, thiab muab kev nyab xeeb kev kho mob rau siab - pab pawg muaj kev pheej hmoo.
Cim npe nrov: Baloxavir Marboxil Powder CAS NO.1985605-59-1, Tuam Tshoj Baloxavir Marboxil Hmoov CAS NO.1985605-59-1 manufacturers, lwm tus neeg, Hoobkas
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