Etelcalcetide 99% Cas No.1262780-97-1

Peb tshwj xeeb hauv kev muab siab -purity Etelcalcetide active pharmaceutical ingredient (API). Cov khoom no nruj me ntsis ua raws li kws tshuaj- qib cov qauv zoo, muaj cov qauv tshuaj lom neeg (CAS 1262780-97-}1), thiab ntiav cov txheej txheem tsim khoom nruj thiab tswj cov txheej txheem kom ntseeg tau batch-rau-batch sib xws thiab ruaj khov.

Peb API yog tsim los ua kom tau raws li qhov yuav tsum tau ua nruj me ntsis thoob plaws txhua theem, los ntawm kev tshawb fawb preclinical mus rau kev lag luam ntau lawm. Nrog lub peev xwm hloov tau los ntawm gram mus rau kilogram kom muaj nuj nqis, peb tau cog lus los muab kev txhawb nqa cov saw hlau txhim khu kev qha rau koj qhov kev tsim kho tshiab thiab kev tshawb fawb kho tshiab, sib koom ua ke txhim kho kev siv tshuaj peptide tseem ceeb no.

Etelcalcetide yog ib qho tshiab calcimimetic tus neeg sawv cev. Nws ua raws li kev ua ntawm calcium extracellular los ntawm kev ua kom Calcium-Sensing Receptor nyob rau ntawm cov qog parathyroid thiab lwm cov ntaub so ntswg (xws li cov thyroid C-cells), yog li ua rau lub cev ua rau lub cev muaj zog zoo ib yam li siab - ntshav-calcium xeev. Nws lub luag haujlwm tseem ceeb yog txhawm rau txhawm rau txhawm rau hyperplasia thiab oversecretion ntawm parathyroid thawj cov hlwb, ua rau lub cev thiab muaj zog txo qis hauv kev nthuav dav Parathyroid Hormone ntau ntau.

1. Allosteric Activation:Etelcalcetide ua raws li qhov zoo allosteric modulator, tshwj xeeb khi rau lub transmembrane domain ntawm Calcium-Sensing Receptor ntawm parathyroid cell membranes.

2. Enhanced Sensitivity:Qhov kev khi no tsis ncaj qha qhib lub receptor tab sis ua rau nws muaj kev nkag siab zoo rau cov calcium extracellular calcium ions, ua rau cov receptor yooj yim qhib txawm tias nyob hauv ib txwm lossis me ntsis ntshav calcium concentrations calcium concentrations.

3. Teeb liab Transduction & Secretion Inhibition:Thaum receptor activation, downstream signaling pathways (piv txwv li, Gq/11-PLC-IP3 txoj kev) tau pib, thaum kawg ua rau kev tso tawm calcium los ntawm cov khw muag khoom intracellular thiab nce hauv cytosolic calcium concentration. Qhov no zoo inhibits qhov tso tawm thiab tso tawm ntawm cov tshuaj ua ntej ua rau Parathyroid Hormone.

Raws li qhov siab -purity Active Pharmaceutical Ingredient (API), qhov ua tau zoo ntawm Etelcalcetide tau paub los ntawm qhov kev txiav txim siab kho mob uas nws muab rau cov khoom siv tshuaj tiav. Raws li nws qhov tseeb pharmacological mechanism, nws cov txiaj ntsig tseem ceeb suav nrog:

• Muaj peev xwm txo PTH:Tsis tu ncua thiab ruaj khov txo qis cov ntshav siab tsis zoo Parathyroid Hormone qib hauv cov neeg mob hemodialysis.

• Kev tswj cov pob txha Mineral Metabolism:Pab txhim kho cov teeb meem ntawm calcium thiab phosphorus metabolism tshwm sim los ntawm theem nrab hyperparathyroidism, pab txo qis ntawm hyperphosphatemia.

• Ntev-Kev Ua Haujlwm & Yooj Yim:Vim nws qhov kev tsim tshuaj tshwj xeeb (muaj D-amino acids, tiv thaiv kev puas tsuaj), nws tso cai rau kev tswj hwm cov hlab ntsha tom qab hemodialysis, muab kev ua tau zoo thiab txhawb nqa cov neeg mob kom yooj yim.

Cov khoom no, raws li API uas ua raws li cov qauv nruj nruj, feem ntau yog siv rau hauv cov hauv qab no:

• Kev Tsim Tshuaj Tshuaj:Siv nyob rau hauv kev npaj cov tshuaj txhaj rau kev kho mob theem nrab hyperparathyroidism nyob rau hauv cov neeg laus cov neeg mob uas muaj mob raum mob nyob rau hauv hemodialysis.

• Tshuaj R&D tshiab:Ua haujlwm raws li cov khoom xyaw tseem ceeb rau kev tsim cov qauv tshiab (piv txwv li, txhaj tshuaj sib txawv), cov tshuaj txhim kho, lossis cov khoom sib xyaw ua ke.

• Kev tshawb fawb soj ntsuam:Muab rau cov tuam txhab tshuaj thiab cov chaw tshawb fawb rau kev tshawb fawb txog bioequivalence, hauv -qhov tob pharmacological- kev tshawb fawb tshuaj thiab tshuaj toxicological tob, thiab lwm yam kev tshawb fawb soj ntsuam.

Tsis lees paub:

Cov ntaub ntawv saum toj no yog ua raws li kev tshaj tawm kev tshawb fawb thiab cov ntaub ntawv kho mob pej xeem thiab yog muab rau kev siv nkaus xwb. Cov khoom no yog Active Pharmaceutical Ingredient (API) tsuas yog siv los ntawm cov kws tshaj lij hauv kev tshawb fawb thiab kev tsim tshuaj. Nws yuav tsum tsis txhob siv ncaj qha rau tib neeg lossis siv los ua cov khoom siv tshuaj tiav.

Cim npe nrov: Etelcalcetide 99% CAS No.1262780-97-1, Tuam Tshoj etelcalcetide 99% cas no.1262780-97-1 manufacturers, lwm tus neeg, Hoobkas