Setmelanotide hmoov CAS No.920014-72-8
Khoom Source: Synthetic
Assay Specification: Ntau dua lossis sib npaug li 98%
CAS Nr .: 920014-72-8
Txoj Kev Xeem: HPLC
Cov khoom xyaw nquag: Setmelanotide
Chemical Formula: C₁₅₈H₂₅₄N₄₆O₄₅S₇
Molecular Luj: 3647.02 g / mol
Cov Khoom Muag: Dawb rau tawm -dawb lyophilized hmoov.
Cov Khoom Siv: Kev siv tshuaj thiab kev tshawb fawb
Cia Cov Cuab Yeej: Txias ntawm 2℃-8 degree, tiv thaiv lub teeb thiab noo noo
Lub neej txee: 24 lub hlis
Khoom Description
Xi'an Tihealth High -Quality Setmelanotide Hmoov
Xi'an Tihealth Biotechnology Co., Ltd.muaj -zoo, siab - specification, siab -cov ntsiab lus Setmelanotide Powder (Setmelanotide Powder) nrog rau lub hauv paus tseem ceeb ntawm purity siab (Ntau dua los yog sib npaug rau 98%) thiab tshuaj- qib zoo. Ua raws li kev ua raws li Teb Chaws Asmeskas Pharmacopeia (USP) / European Pharmacopoeia (EP) thiab GMP cov qauv, nws tau qhia rau kev kho mob ntawm kev rog dhau los ntawm POMC / LEPR noob hloov. Cov khoom tau dhau los ua ntau qhov kev sim suav nrog HPLC thiab huab hwm coj spectrometry kom ntseeg tau tias muaj pes tsawg leeg thiab tswj cov impurities. Nws zoo nkaus li cov hmoov dawb lyophilized uas yaj mus rau hauv cov kua ntshiab, ua tau raws li qhov yuav tsum tau ua rau cov tshuaj txhaj tshuaj. Leveraging khoom-theem synthesis technology thiab kev tswj xyuas zoo, nws qhia tau hais tias zoo batch sib xws thiab 24-hli cia stability ntawm 2-8℃. Tau dhau los ntawm ntau qhov kev lees paub, nws muab cov ntaub ntawv raw khoom raws kev cai thiab txhim khu kev qha rau cov tsev kho mob, kev tshawb fawb, thiab cov neeg siv tshuaj.
Cov khoom muaj nuj nqi
Setmelanotide ua haujlwm raws li kev xaiv MC4R agonist, kho cov teeb meem tsis zoo hauv cov neeg mob POMC/LEPR- cuam tshuam txog kev rog. Nws hais txog lub hauv paus ua rau muaj kev tshaib kev nqhis ntau dhau thiab qhov hnyav nce los ntawm kev hloov pauv kev qab los noj mov thiab kev siv hluav taws xob.
Mechanism ntawmAckev
Cov tshuaj khi rau thiab ua kom lub MC4R nyob rau hauv lub hypothalamus, ib tug tseem ceeb regulator ntawm lub zog tshuav nyiaj li cas. Hauv cov neeg mob uas muaj POMC lossis LEPR kev hloov pauv (uas cuam tshuam kev cuam tshuam endogenous MC4R signaling), Setmelanotide bypasses genetic defects rau normalize qab los noj mov thiab kev tswj metabolic.
Cov khoom Appdaim ntawv qhia
Pom zoo siv:Kev kho mob ntawm POMC deficiency lossis LEPR deficiency rog (tsis tshua muaj caj ces mob).
Kev tshawb fawb muaj peev xwm:Kev tshawb nrhiav hauv kev rog rog- cuam tshuam txog kev sib kis (xws li, ntshav qab zib, kev pheej hmoo plawv) thiab lwm yam MC4R- cuam tshuam txog cov kab mob metabolic.
Pharmaceutical Development:Raws li ib tug raw khoom rau txhaj tshuaj formulations nyob rau hauv kev kho mob thiab preclinical kev tshawb fawb.
Pharmacological teebmeem
Central Effects:Txo kev tshaib kev nqhis, nce satiety, thiab txo cov calories kom tsawg.
Cov teebmeem ntawm metabolic:Txhim kho kev siv hluav taws xob thiab txhim kho lub cev muaj pes tsawg leeg (txo cov rog rog).
Ntev -Cov txiaj ntsig tau ntev:Kev sim tshuaj kho mob qhia tau tias poob phaus (10-30% ntawm cov hauv paus ntsiab lus) tshaj 52 lub lis piam hauv cov neeg mob cov neeg mob.
Toxicological teebmeem
Common Adverse Events:Kev txhaj tshuaj me me mus rau nruab nrab- qhov tshwm sim ntawm qhov chaw, hyperpigmentation (vim yog melanocortin receptor activation), thiab cov ntshav siab nce ntxiv.
Safety Profile:Feem ntau zoo- zam rau hauv kev sim tshuaj; tsis muaj qhov tseem ceeb ntawm lub cev toxicity qhia.
Contraindications:Tsis pom zoo rau cov neeg mob uas muaj kev ua haujlwm MC4R txoj hauv kev (ib txwm teeb liab) vim muaj peev xwm ua rau muaj kev pheej hmoo ntau dhau.
Cim npe nrov: Setmelanotide hmoov cas No.920014-72-8, Suav teb setmelanotide hmoov cas no.920014-72-8 manufacturers, lwm tus neeg, Hoobkas
You Might Also Like
Xa kev nug