Desloratadine hmoov CAS No.100643-71-8

Desloratadine Powder yog ib qho siab -purity hluavtaws antihistamine tshuaj yeeb tshuaj, ua haujlwm metabolite (de-ethoxycarbonyl derivative) ntawm Loratadine. Cov khoom lag luam zoo nkaus li dawb rau tawm -dawb crystalline hmoov, tsis muaj ntxhiab tsw lossis nrog cov ntxhiab tsw ntxhiab tsw; Cov dej tsis tshua muaj dej solubility (kwv yees li 0.1 mg / mL), yooj yim soluble hauv cov kuab tshuaj organic xws li ethanol thiab dimethyl sulfoxide (DMSO); purity Ntau dua lossis sib npaug li 98% (High Performance Liquid Chromatography, HPLC).

Lub luag haujlwm tseem ceeb ntawm desloratadine hmoov yog xaiv los tiv thaiv histamine -kev tsis haum tshuaj sib haum xeeb, tshwj xeeb suav nrog:

1. Thaiv H₁ receptor signaling: Los ntawm kev xaiv ntau khi rau histamine H₁ receptors nyob rau hauv cov ntaub so ntswg peripheral (xws li qhov ntswg mucosa, daim tawv nqaij, thiab plab hnyuv ib ntsuj av), nws tiv thaiv histamine los ntawm khi rau nws receptors. Qhov no inhibits histamine-induced vasodilation, nce permeability, du nqaij contraction (xws li, qhov ntswg congestion, daim tawv nqaij urticaria), thiab glandular secretion (xws li, rhinorrhea, lacrimation).

2. Tsis yog- cov nyhuv sedating: Vim nws cov qauv molecular uas tsis yooj yim hla cov ntshav- hlwb teeb meem, nws cuam tshuam rau H₁ receptors hauv nruab nrab paj hlwb, uas ua rau tsis tshua muaj tshwm sim ntawm thawj- tiam antihistamines xws li qaug zog lossis qaug zog;

3. Adjuvant los tiv thaiv- inflammatory teebmeem: inhibits qhov tso tawm ntawm inflammatory mediators xws li leukotrienes thiab prostaglandins los ntawm mast hlwb thiab eosinophils, yog li txo inflammatory puas nyob rau hauv cov kev tsis haum tshuaj (xws li, qhov ntswg mucosal o nyob rau hauv allergic rhinitis, daim tawv nqaij liab thiab o nyob rau hauv urticaria).

Desloratadine hmoov yog siv rau hauv kev lag luam tawm txawv teb chaws, kev tshawb fawb tshawb fawb, thiab tshuaj reagents.

Cov txheej txheem ntawm kev txiav txim ntawm desloratadine koom nrog ntau qhov kev cuam tshuam ntawm kev tsis haum tshuaj, nrog rau nws cov haujlwm tseem ceeb yog xaiv peripheral H₁ receptor blockade.