Bupivacaine Powder Cas No.2180-92-9
Cov khoom siv: Kev npaj los ntawm condensation cov tshuaj tiv thaiv ntawm piperidine nplhaib thiab aromatic amine tebchaw los ntawm cov khoom siv tshuaj hluavtaws
Cov ntsiab lus tshwj xeeb: Ntau dua lossis sib npaug rau 99.0%
CAS Nr .: 2180-92-9
Cov tshuaj molecule: C ₁₈ H ₂₈ N ₂ O (molecular formula)
Txoj kev kuaj pom: HPLC (USP / UP)
Mechanism ntawm kev txiav txim: Los ntawm thaiv cov sodium raws ntawm cov hlab ntsha cell membrane, nws inhibits tiam thiab conduction ntawm paj hlwb impulses, li no exerting cov tshuaj loog hauv zos cov teebmeem. Nws belongs rau amide - hom ntev - ua tshuaj loog hauv zos.
Cov khoom xyaw nquag: Bupivacaine
Khoom mesh loj: 100-120 mesh
Product Description: Dawb los yog tawm dawb crystalline hmoov
Khoom siv: Bupivacaine Powder feem ntau yog siv rau hauv thaj chaw tshuaj loog hauv tshuaj
Cov khoom ntim: 1KG nyob rau hauv aluminium foil hnab; 25KG / nruas
Cov khoom cia: Khaws rau hauv qhov chaw qhuav thiab txias, tsis txhob tshav ntuj thiab kub
Lub neej txee: 24 lub hlis
Khoom Description
Xi'an Tihealthsiab -purity Bupivacaine Powder raw khoom
Bupivacaine Powder yog ib lub sijhawm ntev - ua amide- hom tshuaj loog hauv zos, dav siv hauv kev kho mob rau cov tshuaj loog hauv cheeb tsam thiab hauv zos vim nws muaj zog thiab mob ntev - thaiv kev cuam tshuam. Ua ntej sib xyaw ua ke hauv xyoo 1950s thiab tau pom zoo rau kev siv kho mob hauv xyoo 1960, nws yog nyob rau hauv tib chav kawm li lidocaine thiab ropivacaine tab sis sawv tawm rau nws lub sijhawm ntev ntawm kev ua haujlwm- ua rau nws xaiv qhov kev xaiv rau cov txheej txheem uas yuav tsum tau ua ntev - tswj qhov mob ntev. Chemically, nws muaj ib tug molecular mis ntawm C18H28N2O, nrog ib tug qauv featuring ib tug aromatic nplhaib, ib tug amide linkage, thiab ib tug tertiary amine pab pawg neeg - cov qauv amide no pab txhawb rau nws stability (resistant hydrolysis) thiab tsis tshua muaj kev pheej hmoo ntawm kev tsis haum tshuaj piv rau ester- hom tshuaj loog hauv zos (xws li.
Cov Khoom Zoo
Kev sib tw kom zoo dua
Lub siab -purity Bupivacaine Powder raw khoom ntawmXi'an Tihealth Biotechnology Co., Ltd.muab kev nyab xeeb thiab txhim khu kev qha raw khoom guarantees rau thaj chaw tshuaj, tshuaj pleev ib ce, thiab lwm yam nrog cov hauv qab no cov txiaj ntsig zoo uas tau raug txheeb xyuas los ntawm cov tub ceev xwm:
Qhov zoo thiab qhov tseeb tshaj qhov kev txwv kev lag luam
01
Tag nrho scenario ua raws li daim ntawv pov thawj system
02
Txiav ntug ntau lawm technology kom ruaj khov
03
Pob tshab traceability thiab xoom yuam kev ntau lawm
04
Tus nqi davhlau ya nyob twg ntawm tus nqi txo thiab txhim kho kev ua haujlwm
05
Tihealth Bupivacaine Powder txhais cov ntaub ntawv zoo nrog cov ntaub ntawv - Ua kom txhua gram ntawm raw khoom tiv thaiv ob qho kev tshuaj xyuas los ntawm electron microscopy thiab cov koom haum tswj hwm tshuaj thoob ntiaj teb.
Cov khoom COA
Certificate of Analysis
| Khoom npe | Bupivacaine hmoov | Batch No. | TIAB SA 20250305 |
|---|---|---|---|
| Hnub tsim khoom | 2025-03-05 | Hnub Kawg | 2027-03-02 |
| Cov khoom kuaj | Cov txiaj ntsig / Specification | Kev lees txais | Daim ntawv pov thawj |
| Qhov tshwm sim | Dawb crystalline hmoov | - | EP 2.2.1 |
| Solubility (H₂O, 25 degree) | Ntau dua lossis sib npaug li 50mg / mL | - | EP 2.9.1 |
| pH (5%) | 4.5–5.5 | 4.0–6.5 | EP 2.2.3 |
| Crystal Form | Hom I polymorph | Zoo ib yam | XRD (USP 941〉) |
| Kev ntsuam xyuas (HPLC) | 99.97% | Ntau dua lossis sib npaug li 99.95% | EP 2.2.29 |
| Loj tshaj plaws Unknown Impurity | 0.018% | Tsawg dua lossis sib npaug li 0.10% | EP 2.2.46 |
| Tag nrho cov impurities | 0.028% | Tsawg dua lossis sib npaug li 0.30% | EP 2.2.46 |
| Residual Solvent (DMF) | <1ppm (N.D.) | Tsawg dua lossis sib npaug rau 880ppm (ICH Q3C) | GC-MS (EP 2.2.28) |
| Heavy Metals (Pb, As, thiab lwm yam) | 0,8ppm ua | Tsawg dua lossis sib npaug li 1.0ppm | ICP-MS (EP 2.4.20) |
| Cov kab mob endotoxins | <0.05 EU/mg | Tsawg dua lossis sib npaug rau 0.083 EU / mg | EP 2.6.14 |
| Hemolysis tus nqi (0.6% sol.) | 0.55% | Tsawg dua lossis sib npaug li 0.6% (ChP Tsawg dua lossis sib npaug li 5%) | PIB 2020 |
| Micronucleus Test | Tsis zoo | Tsis zoo | TIAB SA 474 |
| Sterility Test | Ua raws | - | EP 2.6.1 |
| Ceev (40℃/ 6M) | Purity poob Tsawg dua lossis sib npaug li 0.05% | - | ICH Q1A (R2) |
| Ntev -lub sij hawm (25℃/ 24M) | Tag nrho impurities Tsawg dua lossis sib npaug li 0.35% | - | ICH Q1A (R2) |
| Kev thauj mus los | -20℃Dedicated Cold Chain | Crystal qauv tiv thaiv | ISO 15378 Kev Tswj Xyuas Kev Lag Luam |
| Daim ntawv pov thawj | Tuam Tshoj GMP 2025, ISO 13485: 2016 | - | FDA DMF No. 033779 |
| Traceability | Kev tshawb xyuas online ntawm QR code | Tiag -time data access | TKYBIO Huab Platform |
Cov khoomMuaj nuj nqi
Cov ntsiab lus tseem ceeb ntawm cov txiaj ntsig kev noj qab haus huv ntawm Bupivacaine Powder (suav nrog cov liposomal formulations) raws li cov ntaub ntawv tshawb fawb soj ntsuam, nruj me ntsis raws li cov ntaub ntawv pov thawj thiab cov ntaub ntawv siv tshuaj:
1, Lub sij hawm ntev analgesia, optimizing postoperative rov qab
2, Qhov tseem ceeb txo qhov kev cia siab ntawm opioid thiab cov kev mob tshwm sim
3, Txhim kho perioperative kev nyab xeeb
4, Ua kom rov qab sai thiab txhim kho lub sijhawm ntev - kev kwv yees
Cov ntsiab lus
Tus nqi kho mob tseem ceeb ntawm Bupivacaine Powder (tshwj xeeb tshaj yog liposomal formulations) nyob hauv:
✅ Kev ua kom ntev ntev (72 teev tso tawm)
✅ txo Opioid (txo ntau npaum li 61-78%)
✅ Kev txhim kho kev nyab xeeb (kev pheej hmoo xeev siab ↓ 46%, toxicity controllable)
✅ Kev kho kom rov zoo dua qub (mob tsev kho mob luv luv + kho kom zoo dua qub)
Nws cov txiaj ntsig tau dhau los ua ib qho tseem ceeb ntawm cov tshuaj tua kab mob multimodal hauv cov xwm txheej xws li cov hlab ntsha peripheral, kev hloov pauv, thiab kev phais qhov ncauj.
Cov khoom siv
Cov kev siv tseem ceeb ntawmTihealthsiab -purity Bupivacaine Powder npog:
✅ phais tshuaj loog
Nerve block/spinal anesthesia
✅Postoperative analgesia
Ultra ntev ua yeeb yam xav tau xws li kev sib koom ua ke, kev phais thoracic, thiab lwm yam.
✅ mob mob
Mob Cancer, mob Neuropathic
✅ High-end tshuaj pleev ib ce
Transdermal analgesics
Kev siv tshuaj kho mob ntawm Bupivacaine Powder Hom
| Daim ntawv thov Scenario | Bupivacaine Hmoov Hom | Qhov Zoo Tshaj Plaws |
|---|---|---|
| Tom qab -arthroplasty analgesia | Liposomal Bupivacaine hmoov | 72h txhawb nqa analgesia, ↓78% siv opioid |
| Epidural tshuaj loog rau kev ua haujlwm | Standard Bupivacaine hmoov | Lub cev muaj zog-sensory dissociation, tsis muaj zog qeeb |
| Tshuaj pleev ib ce ntawm daim tawv nqaij | Cosmetic-qib (HL-B01 batch) | Tsis yog -carcinogenic, kev nyab xeeb transdermal absorption |
| Mob ntev neuropathic | Liposomal + standard mix | Lub sij hawm ncua ntev (4-6 lub lis piam) |
ProductionNtim
Kev Them Nyiaj
Txoj kev xa khoom
Cov khoomFAQ
Q: Dab tsi yog qhov tshwm sim ntawm kev siv bupivacaine? Loj?
A: Cov kev mob tshwm sim feem ntau suav nrog xeev siab, ntuav, cem quav (nrog rau qhov tshwm sim ntawm li 10% txog 15%), thiab qee tus neeg yuav ua npaws lossis liab thiab o ntawm qhov chaw txhaj tshuaj. Feem ntau cov tshuaj tiv thaiv me me thiab tuaj yeem txo tus kheej yam tsis muaj kev kho tshwj xeeb. Cov kev mob tshwm sim hnyav, xws li arrhythmia thiab ua pa nyuaj, tsis tshua muaj tab sis xav tau kev kho mob tam sim.
Q: Kuv hnov tias bupivacaine muaj mob toxicity, puas muaj tseeb?
A: Yog lawm, lub plawv toxicity ntawm bupivacaine yog plaub npaug ntawm lidocaine, tab sis qhov kev pheej hmoo tseem ceeb tsuas yog thaum siv ntau dhau lossis ua rau cov hlab ntsha. Raws li kev kho mob tus txheej txheem ntau npaum li cas (ib koob tshuaj tsawg dua lossis sib npaug li 200mg), cov tshuaj ntshav ntshav siab nyob deb ntawm qhov pib muaj tshuaj lom, thiab kev nyab xeeb yog tswj tau. Cov kws kho mob yuav nruj me ntsis saib xyuas cov koob tshuaj thiab muab kev ntsuas kub ceev.
Q: Kev txhaj tshuaj bupivacaine ntev npaum li cas? Puas yog nws muaj zog dua li kev siv tshuaj loog?
A: Tsis tu ncua bupivacaine: kav ntev li 2-8 teev (xws li tshuaj loog rau kev tshem tawm cov hniav thiab kev phais me);
Kev npaj liposome: Nruam analgesia rau 72 teev los ntawm kev txhawb nqa -tso tawm tshuab (tsim rau kev phais loj xws li kev hloov pauv). Lub sijhawm ua haujlwm yog 2-3 zaug ntawm lidocaine, uas tuaj yeem txo qhov xav tau kev txhaj tshuaj dua.
Q: Nws puas tuaj yeem siv thaum cev xeeb tub / lactation? Nws puas yuav cuam tshuam rau tus menyuam hauv plab?
Muaj: 0.25% low concentration tov yog pom zoo rau kev xa cov tshuaj loog epidural, nrog cov placental permeability thiab validated kev nyab xeeb;
Txwv: 0.75% siab concentration yog txwv tsis pub thaum lub sij hawm xa tuaj (kev pheej hmoo ntawm plawv nres);
Lub sij hawm pub niam mis: Ib qho me me ntawm cov kua mis nkag, tab sis qhov kev pheej hmoo tsawg thiab yuav tsum tau soj ntsuam los ntawm kws kho mob.
Q: Kev phais menyuam puas tuaj yeem siv tau? Puas yog cov laus?
Cov menyuam yaus hnub nyoog siab dua lossis sib npaug li 12 xyoos: Liposomal bupivacaine (dose 4mg / kg) tuaj yeem siv tau;
Cov neeg laus: Yuav tsum tau txo qhov ntau npaum li cas, vim tias cov metabolism hauv qeeb yuav ua rau tsub zuj zuj;
Kev ceev faj yuav tsum tau them rau: siv ceev faj rau cov neeg uas muaj lub siab ua haujlwm tsis zoo, thiab siv ceev faj rau cov neeg muaj lub raum tsis ua haujlwm.
Cim npe nrov: Bupivacaine Powder Cas No.2180-92-9, Tuam Tshoj Bupivacaine Hmoov Cas No.2180-92-9 manufacturers, lwm tus neeg, Hoobkas
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