Ubrogeant API Cas No.1374248-77-7
Khoom Keeb Kwm: Siab Synthetic
Specification: Ntau dua lossis sib npaug rau 99.0%
CAS Nr .: 1374248-77-7
Molecular Formula: C₂₉H₂₆F₃N₅O₃
Molecular Luj: 549.55 g / mol
Txoj Kev Xeem: HPLC
Cov khoom xyaw nquag: Ubrogeant
Cov yam ntxwv ntawm cov khoom: Dawb rau tawm -dawb crystalline hmoov
Solubility: Khoom ntim: 1kg / hnab; 25kg / nruas
Kev cia khoom: Tiv thaiv los ntawm lub teeb; khw kaw. Txias ntawm 2-8℃hauv qhov tsaus ntuj. Thaum qhib, siv tam sim ntawd nyob rau hauv ib qho chaw qhuav thiab reseal nrog nitrogen flush.
Lub neej txee: 24 lub hlis
Khoom Description
Xi'an Tinoj qab haus huvkhoom siv siab -zoo Ubrogepant Active Pharmaceutical Ingredient (API)
Nrog nruj ua raws li cGMP thiab ICH cov lus qhia rau kev tswj kom zoo. Siv cov txheej txheem sib xyaw ua ke thiab kev ua kom huv huv, peb cov khoom lag luam tau ua tiav qib purity ntawm ntau dua 99.5%, nrog nruj tswj hwm impurity profiles-txhua tus neeg impurity tseem qis dua 0.15%, ua tau raws li cov qauv siab xav tau los ntawm cov kws tsim tshuaj.
Cov khoom lag luam nthuav tawm cov qauv crystalline ruaj khov thiab solubility zoo heev, ua kom muaj zog batch - rau -batch sib xws thiab muab kev txhawb nqa txhim khu kev qha rau cov neeg siv khoom tsim thiab tsim khoom. Nrog rau kev tshawb fawb zoo thiab muaj peev xwm tsim tau zoo, peb tau ua tau zoo -ntaus kom tau raws li kev xav tau ntawm kev ua lag luam sib txawv-los ntawm kev txhim kho kev kho mob mus rau kev lag luam-theem mov- thiab tau cog lus tias yuav xa cov kev daws teeb meem API zoo, ua raws, thiab ua tau zoo rau peb cov neeg siv khoom thoob ntiaj teb.
Cov khoom muaj nuj nqi
Ubrogepant API yog qhov siab -purity active tshuaj muaj nyob rau hauv formulation thiab manufacturing ntawm cov khoom tiav lawm tshuaj (ntsiav tshuaj). Nws ua haujlwm raws li lub zog muaj zog thiab xaiv antagonist ntawm tib neeg calcitonin noob -txog peptide (CGRP) receptor.
Cov lus qhia:
Cov khoom siv tshuaj uas tsim los siv Ubrogepant API yog qhia rau kev kho mob migraine nrog lossis tsis muaj aura hauv cov neeg laus. Nws tsis yog qhia rau kev kho mob prophylactic ntawm migraine.
Mechanism ntawm Akev txiav txim
Ubrogepant yog calcitonin gene -related peptide (CGRP) receptor antagonist. Nws ua haujlwm los ntawm kev xaiv thaiv kev khi ntawm CGRP neuropeptide rau nws cov receptors. CGRP yog tus kws kho mob tseem ceeb koom nrog hauv pathophysiology ntawm migraine, vim nws txhawb nqa vasodilation ntawm cov hlab ntsha cranial, xa cov cim mob, thiab ua rau muaj kev mob neurogenic. Los ntawm inhibiting CGRP txoj hauv kev, Ubrogepant thim rov qab cov txheej txheem no, yog li txo qhov mob migraine thiab cov tsos mob cuam tshuam.
Cov khoom Apdaim ntawv thov
Thawj daim ntawv thov ntawm Ubrogeant API yog nyob rau hauv kev tsim tshuaj. Nws yog siv los ua cov khoom siv raw (cov khoom siv tshuaj ntau) rau kev tsim cov ntaub ntawv ntawm qhov ncauj, tshwj xeeb:
Zaj duab xis- cov ntsiav tshuaj coated (piv txwv li, 50 mg thiab 100 mg muaj zog). Cov khw muag tshuaj yuav ua cov API los ntawm ntau theem, suav nrog kev tsim, granulation, sib tov, compression, thiab txheej, los tsim cov tshuaj lag luam zaum kawg npaj rau tus neeg mob siv.
Pharmacological teebmeem
Therapeutic nyhuv:Kev kho sai sai los ntawm qhov mob nruab nrab mus rau mob taub hau mob taub hau, nrog rau cov tsos mob xws li photophobia, phonophobia, thiab xeev siab.
Selectivity:Ua kom pom kev sib raug zoo siab thiab kev xaiv rau tib neeg CGRP receptor, nrog rau kev ua haujlwm tsawg kawg ntawm lwm cov receptors (piv txwv li, adrenomedullin, amylin receptors), txo cov peev xwm rau kev tawm tsam - cov kev mob tshwm sim.
Vascular Effects:Inhibits CGRP-induced vasodilation nyob rau hauv cov hlab ntsha cranial tsis ua rau vasoconstriction, uas txawv nws los ntawm cov laus ergotamine thiab triptan tshuaj.
Central thiab Peripheral teebmeem:Ua ob qho tib si peripheral ntawm lub paj hlwb trigeminal thiab muaj peev xwm nyob rau hauv lub hauv paus paj hlwb los hloov kho txoj kev mob.
Tsis muaj pov thawj ntawm kev tsim txom:Hauv kev tshawb fawb tib neeg, Ubrogepan tsis pom tias tsis muaj cov cim qhia txog kev tsim txom lossis kev vam meej.
Cim npe nrov: ubrogepant api cas no.1374248-77-7, Tuam Tshoj ubrogepant api cas no.1374248-77-7 manufacturers, lwm tus, Hoobkas
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