Cyclophosphamide Powder Cas No.50-18-0

Cyclophosphamide yog ib qho hluavtaws nitrogen mustard alkylating tus neeg sawv cev nrog dav -spectrum antitumor kev ua haujlwm thiab muaj zog tiv thaiv kab mob. Raws li ib tug prodrug, nws yuav tsum tau ua kom lub siab nyob rau hauv vivo ua active. Nws inhibits kev loj hlob ntawm cov cell proliferating sai heev (xws li, qog hlwb, lymphocytes) los ntawm kev cuam tshuam nrog DNA replication thiab transcription.

1. Antitumor Function:Raws li tsis yog - tus neeg sawv cev ntawm lub voj voog tshwj xeeb, nws ncaj qha cuam tshuam cov qog cell DNA qauv, tiv thaiv kev faib tawm thiab kev loj hlob.

2. Immunosuppressive Function:Txhawb nqa kev loj hlob thiab kev ua haujlwm ntawm T lymphocytes thiab B lymphocytes, yog li tswj cov kab mob tsis zoo.

1. Oncology:Dav siv los kho ntau yam malignancies, suav nrog tsis yog-Hodgkin lymphoma, Hodgkin lymphoma, ntau yam myeloma, leukemia, mob qog noj ntshav mis, mob qog noj ntshav ntawm zes qe menyuam, thiab neuroblastoma.

2. Rheumatology thiab Immunology:Siv los kho cov kab mob autoimmune hnyav tsis teb rau lwm cov tshuaj, xws li kab mob lupus erythematosus (tshwj xeeb yog lupus nephritis), rheumatoid mob caj dab, granulomatous polyangiitis, microscopic polyangiitis, thiab scleroderma.

Cyclophosphamide nkag mus rau oxidative metabolism hauv lub siab ntawm cytochrome P450 enzyme system, tsim cov tshuaj pharmacologically nquag metabolite 4-hydroxycyclophosphamide. Qhov no active metabolite yog ntxiv thauj mus rau lub hom phiaj cov ntaub so ntswg, qhov twg nws lov rau hauv phosphoramide nitrogen mustard nrog muaj zog alkylating kev ua si. Phosphoramidite nitrogen mustard cross-links nrog guanine hauv paus ntawm DNA strands, cuam tshuam cov qauv helix ob npaug. Qhov no impedes DNA replication, transcription, thiab RNA synthesis, thaum kawg ua rau cell tuag los ntawm kev cuam tshuam ntawm noob caj noob ces cov ntaub ntawv.

1. Cov teebmeem kev kho mob:

  • Cov teebmeem Antitumor:Ncaj qha puas qog cell DNA, inducing qog shrinkage los yog regression.

  • Cov teebmeem Immunosuppressive:Qhov tseem ceeb txo qis cov lymphocyte circulating suav thiab suppresses antibody ntau lawm, yog li tswj kev loj hlob ntawm cov kab mob autoimmune.

2. Kev Tsis Pom Zoo:

  • Myelosuppression:Ua rau leukopenia thiab thrombocytopenia, nce kab mob thiab los ntshav txaus ntshai.

  • Urinary Toxicity:Cov metabolite acrolein tuaj yeem ua rau hemorrhagic cystitis; ntev - siv sij hawm ua rau muaj kev pheej hmoo mob qog noj ntshav.

  • Gastrointestinal Reactions:Feem ntau xeev siab, ntuav, thiab tsis qab los noj mov.

  • Cov teebmeem ntawm kev yug menyuam:Tej zaum yuav ua rau muaj menyuam tsis taus thiab amenorrhea.

  • Lwm yam:Xws li alopecia, qhov ncauj mucositis, thiab muaj kev pheej hmoo ntawm kev mob qog nqaij hlav thib ob (xws li leukemia).