Ziconotide hmoov CAS No.107452-89-1
English alias: Prialt
Khoom qhov chaw: artificially synthesized
Khoom specifications: Ntau tshaj los yog sib npaug rau 99%
CAS Nr .: 107452-89-1
Txoj kev kuaj pom: HPLC
Cov khoom xyaw nquag: Zyconomide Acetate
Cov lus piav qhia ntawm cov khoom: Dawb kom tawm dawb khov - cov hmoov qhuav
Khoom siv: Intrathecal txhaj tshuaj analgesic rau kev kho mob ntawm refractory mob ntev
Cov khoom ntim: 1mg-100mg / lub raj mis; 10 fwj / thawv
Cov khoom cia: Khaws rau hauv qhov tsaus ntuj thiab qhuav qhov chaw ntawm -20℃± 5 degree
Lub neej txee: 24 lub hlis
Khoom Description
Xi'an Tihealth Ziconotide Product Overview
Peb lub tuam txhab muab siab -purity ziconomide (CAS 107452-89-1) nrog lub ntsiab purity ntawm Ntau dua lossis sib npaug li 98% (HPLC), uas tuaj yeem ua tau raws li kev xav tau ntawm kev lag luam. Cov khoom yog muab nyob rau hauv daim ntawv ntawm khov-qhuav hmoov (dawb mus rau dawb), nrog tag nrho -20℃txias saw tsheb thauj mus los, nruab nrog tag COA, thiab txhawb customized tshuaj specifications xws li 1mg mus rau kg. Cov khoom no yog tsim tshwj xeeb rau kev txhim kho cov tshuaj analgesic formulations thiab tsim nyog rau kev tshawb fawb thiab GMP zus tau tej cov intrathecal tshuaj xa tshuab, pab cov neeg muas zaub kov yeej lub bottleneck ntawm refractory neuropathic mob.
Cov khoomMuaj nuj nqi
Kev ua xua kom zoo: tshwj xeeb yog thaiv N- hom voltage-gated calcium channels (Cav2.2) ntawm cov hlab ntsha thiab cov leeg txha caj qaum dorsal horn neurons, inhibits mob teeb liab transduction, thiab yog haum rau refractory neuropathic mob uas tshuaj analgesics ib txwm siv tsis tau.
Mechanism ntawm kev ua
1. Lub hom phiaj khi→ Xaiv khi rau Cav2.2 raws hauv cov kab mob presynaptic ntawm tus txha caj qaum dorsal horn neurons → Thaiv calcium influx
2. Teeb liab inhibition→ txo qhov tso tawm ntawm qhov mob neurotransmitters xws li tshuaj P thiab glutamate → cuam tshuam ntawm qhov mob teeb liab kis mus rau hauv nruab nrab lub paj hlwb
Cov khoomKev thov
1. Siv rau hauv kev kho mob
2. Siv rau hauv kev tshawb fawb thiab kev tsim tshuaj tshiab
3. Siv rau hauv kev tshawb fawb txog neuroscience
Pharmacological teebmeem
1. Lub sijhawm ua haujlwm:1-2 teev tom qab kev tswj hwm intrathecal
2. Duration:12-24 teev rau ib qho kev tswj hwm (nruam kev tswj hwm lub twj tso kua mis yog xav tau)
3. Kev kho kom zoo:
✅ Tsis quav ntsej cov tshuaj opioid
✅ Tsis muaj kev pheej hmoo ua pa nyuaj siab
✅ Kev loj hlob qeeb ntawm kev ua siab ntev
Toxicological teebmeem
|
Hom tshuaj toxicity |
Mkev tshwm sim thiabCtswj ntsuas |
|
Neurotoxicity |
koob tshuaj -nyob ntawm kiv taub hau, qhov muag tsis pom kev (tuaj yeem tswj tau los ntawm kev siv tshuaj nruj heev) |
|
Psychological phiv |
Hallucinations, kev nyuaj siab (kev tshwm sim txog 12%, thim rov qab thaum tsis siv tshuaj) |
|
Contraindications |
Cov neeg mob uas muaj keeb kwm mob hlwb raug txwv tsis pub siv; Tsis haum rau kev txhaj tshuaj / intramuscular txhaj (intrathecal nkaus xwb) |
Cim npe nrov: Tuam Tshoj ziconotide hmoov cas no.107452-89-1 manufacturers, lwm tus neeg, Hoobkas
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