Muaj Siab Suav Tshuaj Ntsuab Tshuaj Ntsuab Brownii Extract Ua Kua

Lilium brownii extract kua yog ib tus nqi them nyiaj rov qab los ntawm qhov muag teev ntawmLilium browniiLub hlawv. Ex Miellez ntawm tsawg oveous extraction. Qauv no muaj ntau dua los yog sib npaug rau 5% lilium polysaccharides, qhov no rho tawm cov khoom siv xyoob ntoo thiab cov amino acids, adhering rau Suav pharmacoploeia thiab CGMP cov lus qhia. Qhov zoo tshaj plaws rau cov zaub mov kev noj qab haus huv, cov tshuaj, thiab tshuaj pleev ib ce, nws ua kom zoo nkauj-moisturizing txhawb nqa los ntawm kev tshawb fawb niaj hnub.

Daim Ntawv Pov Thawj Kev Ntsuam Xyuas

1. Kev pab saib kev noj qab haus huv pab txhawb nqa ntawm lub sijhawm nqus dej noo

Hauv cov tshuaj yeeb tshuaj ib txwm, lilium brownii noob tau siv rau millennia los kho "mob ntsws qhuav, kev kho kom zoo los ntawm cov chaw muag khoom niaj hnub. Cov extract ntawm hydysaccharides ua cov txheej txheem tiv thaiv epithelial los ntawm 32% nyob rau hauv lub gobin hyperresponeness hauv ovalbumin-sib tw nas qauv (p<0.01). Concurrently, saponin derivatives inhibit neutrophil elastase activity (IC50=25 μg/mL), mitigating pulmonary inflammation and improving ciliary beat frequency in ex vivo tracheal preparations.

2. Immunomodulatory kev cuam tshuam los ntawm macrophage ua kom

Cov Extract polysaccharide (ntau dua los yog sib npaug rau 5% ua kom pom tseeb (10 { Ntawm cov koob tshuaj ntau dua (100 tus dab \/ ml), nws hloov mus rau M2 Polarization (tiv thaiv il {} {{15} {} tawm. Qhov kev cai lij choj Billirefulity tau lees paub hauv Naj txiv kab ntxwv Larvae tus qauv kis tus qauv, qhov twg cov extract txo E. coli load los ntawm 45% thaum muaj kev mob nqaij ntswg necosis.

3. Kev txiav cov dej ntawm polysaccharide-nplua nuj hygroscopic complexes

Thaum tsim ntawm 1-5% concentration, cov extract tsawg-molecular-phaus polysaccharides (MW<10 kDa) exhibit hygroscopicity 1.8× higher than glycerin, absorbing 200% of their weight in water at 60% RH. In a 4-week clinical trial, a facial serum containing 3% Lilium extract increased skin hydration levels by 28% and reduced transepidermal water loss (TEWL) by 21%, comparable to 0.5% hyaluronic acid. Additionally, saponins enhance stratum corneum permeability, improving the delivery of co-formulated actives by 15-20%.

4. Kev ntxhov siab me me rau kev ntxhov siab ntawm cov kev cai gabaergic

Kev tshawb fawb preclinical hauv Sprague-Dawley nas ua qhia tau tias kev coj tus cwj pwm ntawm qhov kev txiav txim siab ntawm 35%) thiab tsawg dua Plasma Corticosterone ntau qib los ntawm 22%. Cov mechanistically, benzylisoquinibine alkaloids nyob rau hauv extract inhibinase (gaba-t), nce lub hlwb gaba ntau ntawm 18% hauv amygdala. Cov nyhuv no yog sib piv rau cov tshuaj lom roj tsawg tab sis tsis muaj kev mob tshwm sim, txhawb nws cov zaub mov kev ntxhov siab.

Cov Khoom Siv Raw Khoom Siv → Tsawg-Kub Kev Pulverization → nqus dej → nqus dej → soliviling hluav taws xob

1. Raw Khoom Uas Sau

Lub hauv paus: HwmLilium browniiLub hlawv. Ex Miellez qhov muag teev tau los ntawm cov ntawv pov thawj hauv Suav Tshuaj ntsuab hauv Hunan thiab Jiangxi Provinces.

Kev Tswj Xyuas Zoo:

Qhov muag teev rau ntau dua los yog sib npaug rau 3cm hla, xim tsis zoo, thiab tsis muaj pwm \/ cov kab sib txawv.

Tested rau cov hlau hnyav (PB tsawg dua los yog sib npaug rau 2Ppm, tsawg dua lossis sib npaug lossis sib npaug. 1ppm EU MRL) ntawm ICP-MS thiab GC-MS.

Preprocessing: Ceev ntxuav nrog lim dej, ua raws li los ntawm huab cua qhuav kom tsawg dua lossis sib npaug rau 12% cov ntsiab lus noo noo.

2. Tsawg-kub pulverization

Kev ua: Cryogenic sib tsoo ntawm tsawg dua lossis sib npaug rau -20 degree siv cov nitrogen-txias zeb.

Khoom uas tsim tau lawm: Particle loj dua lossis sib npaug rau 80 tus (180μm) kom ua kom ntau tshaj thaj av rau kev rho tawm.

Yam uas pab: Tiv thaiv kev cuam tshuam thermal tsis zoo ntawm cov saponins kub thiab polysaccharides thaum lub sijhawm milling.

3. Ultrasonic Extraction

Cuab tam: Stainless hlau ultrasonic rho tawm tank nrog kev tswj qhov kub.

Tsis:

Hnyav: Purified Dej (10: 1 kua-khoom piv).

Kub: {{50-60 degree (khaws polysaccharide Kev ncaj ncees).

Lub sijhawm: {{{{0 {}} feeb (txhim kho cov kev txuag hluav taws xob los ntawm 25% thiab cov qauv ib txwm).

Lub tshuab: Ultrasonic vuag (40kHz) cuam tshuam cov phab ntsa xovtooj ntawm tes, tso cov tebchaw bioactive zoo li lilium polysaccharides thiab saponins.

4. Kev Pom & Chromatography Purification

Theem 1: Centrifugal pom:

3000 teev rau 15 feeb los tshem tawm cov khib nyiab insolule.

Pom kev pom tseeb ntau dua lossis sib npaug rau 90% kev hloov pauv (ntsuas ntawm 450nm).

Theem 2: Membrane Ultrafiltration:

0.45μm hollow fiber membrane to remove particles >10kda.

Theem 3: Silica gel chromatography:

Tshem tawm cov pigments thiab cov mis nyuj qis-hnyav, yielding ntshiab polysaccharide-nplua nuj extract.

5. Lub tshuab nqus tsev siab

Khoom: Poob zaj duab xis evaporator nyob rau hauv -0. 06Mpa nqus.

Yam xwm txheej:

Kub tshaj lossis sib npaug nrog 50 degree los khaws cia hluav taws kub.

Phiaj ntom ntom: 1. {{10-1. 15 g \/ ml (25 degree), sib npaug nrog 5% polysaccharides.

Pub: {85-90} kev cia siab ntawm cov khoom xyaw nquag tom qab-siab.

6. Kev soj ntsuam zoo

Yuav tsum tau xeem:

Polysaccharides: Phenol-sulfuric acid txujci (ntau dua los yog sib npaug rau 5% w \/ v).

Kua txiv: Vanillin-Sulfuric Acid Assay (ntau dua lossis sib npaug rau 1.5% w \/ v).

Me lug: Tag nrho cov phaj suav tsawg dua lossis sib npaug rau 300cfu \/ g, pwm tsawg dua lossis sib npaug ntawm 100cfu \/ g (aoac 990.12).

Cov hlau hnyav: Icp-ms (pb tsawg dua lossis sib npaug rau 2ppm, tsawg dua lossis sib npaug nrog 1ppm, hg tsawg dua lossis sib npaug}. 5ppm).

Qhia: Thib peb tog coa muab rau txhua pob, suav nrog HPLC DROMATAMS.

7. Lub Ntim Ntim

Chaw nyob: ISO chav kawm 8 (100, {2}} 级 级 级 级 级) chav ntxuav dej nrog Laminar ntws.

Kev Xaiv Ntim:

1kg: FELGE-qib-qib aluminium ntawv ci hnab (nitrogen-flushed rau tsawg dua lossis sib npaug rau 1% o₂).

25Kg: Cardboard drum nrog PE Liners (lub tshuab nqus tsev-sib khi rau kev tiv thaiv noo noo).

Daim fab xwb: Tus lej xov tooj, hnub tas sij hawm, thiab GMP kev ua raws logo luam tawm ntawm kev ntim khoom.

8. Kev faib tawm thoob ntiaj teb

Logistics Cov Tes Haujlwm:

Ua: DHL \/ UPS nrog cov kev xaiv kub-tswj cov kev xaiv (2-8 degree rau rhiab xaj).

Loj: Hiav txwv thauj ntawm Shanghai \/ Qingdao chaw nres nkoj (15-25 hnub rau EU \/ US).

Txhawb Nqa Kev Cai Custom: Cov kev pab ntxivl-tshem tawm rau FDA (Asmeskas) thiab EFSA (EU), suav nrog Daim Ntawv Pov Thawj \/ Kosher Cov Ntaub Ntawv.

Lem sij hawm: {3-7 hnub rau kev kuaj; 14-21 hnub rau OEM xaj.

OEM cov kev pabcuam muab los ntawm Xi'an ti.cealth Co., Ltd. muaj qhov tseem ceeb

Mekas Tsim: Kho polysaccharide: saponin piv

Kev Tswj Xyuas Zoo: GMP-ntawv lees paub cov chaw, kuaj thib peb tog neeg rau txhua pob (COA muab).

Cov cim tsis pub lwm tus paub: Cov kev daws teeb meem dawb nrog cov kev daws teeb meem ceev.

Kev Tswj Cov Cai: Cov Lus Qhia rau FDA, EU Tshuaj Kho Kom Zoo Cai, thiab TGA Ua Raws.

Ua lub tuam txhab biotechnology, tihealth biotechnology lub tuam txhab muab cov kev pab cuam E-Intrycatics nrog cov yam ntxwv hauv qab no:

1. Kev Pabcuam Tshaj Tawm Thoob Ntiaj Teb

2. Kev Pab Cuam Tshuam Logistic

3. Txhawb txoj kev pabcuam dual

Q1: Dab tsi yog lub txee nyob rau hauv tub yees?
A: 36 lub hlis thaum khaws cia rau ntawm 2-8 degree hauv unpoofed thawj ntim.

Q2: Qhov no puas yog rho tawm haum rau vegan formulations?
A: Yog, tsim nyob rau hauv vegan-ntawv pov thawj chaw uas tsis muaj cov khoom xyaw tsiaj uas tsis muaj tsiaj.

Q3: Kuv puas tuaj yeem thov Coai rau kev cai tswj kav?
A: Yog, txhua pob yog nrog los ntawm cov ncauj lus kom ntxaws xws li HPLC, microbiology, thiab cov hlau hnyav.

Cim npe nrov: Muaj Siab Suav Tshuaj Ntsuab Brownii Extract Ua Kua, Tuam Tshoj Siab Txog Suav Tshuaj Ntsuab Brownii Extract Ua Si Cov Khoom Siv, Cov Chaw Muag Khoom, Hoobkas