Cov txiaj ntsig zoo li cas Epalrestat muab cov neeg mob ntshav qab zib?

Raws li kev mob ntshav qab zib muaj ntau dua, muaj qhov tseem ceeb hauv kev saib xyuas kev noj qab haus huv ntawm kev nkag siab thiab daws nws cov teeb meem. Epalrestat, ib leeg tso cai aldose reductase inhibitor (ARI) hauv Suav teb, tau pom muaj txiaj ntsig zoo hauv kev tswj ntshav qab zib peripheral neuropathy (DPN) thiab cuam tshuam txog cov teeb meem microvascular. Kab lus no tshuaj xyuas cov txheej txheem, kev siv tshuaj kho mob, kev nyab xeeb profile, thiab kev sib cuam tshuam ntawm Epalrestat, saib los ntawm cov lo ntsiab muag ntawm cov kws kho mob thiab cov neeg mob, nrog lub hom phiaj ntawm kev txhim kho kev nkag siab thiab muab cov lus qhia paub.

Epalrestatyog tsim los kho mob ntshav qab zib peripheral neuropathy (DPN) los ntawm kev thaiv txoj hauv kev polyol. Cov txheej txheem no txo ​​qis sorbitol buildup hauv hlwb, yog li txo cov hlab ntsha raug mob vim mob ntshav qab zib. Epalrestat, uas yog tib yam tshuaj ntawm nws hom hauv Suav teb, yog qhov tseem ceeb rau kev tswj cov teeb meem cuam tshuam nrog ntshav qab zib

Epalrestat feem ntau muaj nyob rau hauv daim ntawv ntsiav tshuaj (feem ntau ntawm ib koob ntawm 50 mg). Cov neeg mob yuav tsum ua raws li cov lus qhia los ntawm lawv tus kws kho mob:

Dosage: Qhov ntau npaum li cas yog 50 mg peb zaug ib hnub twg, qhov zoo tshaj 30 feeb ua ntej noj mov los txhim kho kev nqus.

Duration ntawm Kev Kho Mob: Nws feem ntau qhia kom tswj kev kho mob tsawg kawg yog 12 lub lis piam, thaum cov neeg mob yuav tsum tau soj ntsuam lawv cov tsos mob neuropathic. Yog tias tsis muaj kev txhim kho pom zoo tom qab lub sijhawm no, tus kws kho mob yuav tsum rov ntsuam xyuas cov phiaj xwm kho mob.

Kev soj ntsuam: Kev ntsuas tsis tu ncua ntawm cov ntshav qabzib, lub siab ua haujlwm, thiab cov ntshav suav tag nrho yog qhov tseem ceeb, nrog rau kev kuaj xyuas qhov hloov pauv ntawm cov zis xim (uas tuaj yeem dhau los ua xim liab-xim av, pom tau tias tsis muaj kev phom sij).

Cov txiaj ntsig kho mob ntawm Epalrestat feem ntau tshwm sim hauv ob theem:

Kev txhim kho thawj zaug:Cov neeg mob tuaj yeem pom qhov txo qis ntawm cov tsos mob, suav nrog txo qhov mob thiab loog, tom qab 4 mus rau 8 lub lis piam ntawm kev pib kho.

Functional Recovery:Cov kev tshawb fawb soj ntsuam pom tau hais tias muaj kev txhim kho tseem ceeb hauv cov hlab ntsha kev nrawm thiab txo qis hauv cov tsos mob neuropathic tom qab 12 lub lis piam ntawm kev kho. Nws raug nquahu kom ua tiav tag nrho cov phiaj xwm kho mob kom tau txais txiaj ntsig zoo tshaj plaws

Kev tshawb fawb soj ntsuam pom tau hais tias kev siv sijhawm ntev ntawm epaetilate muab cov txiaj ntsig zoo rau cov neeg mob ntshav qab zib:

Enhanced Nerve Function:Epaetilate zoo txo ​​qis cov qhab nia neuropathy thiab tseem ceeb txhim kho cov hlab ntsha nrawm, yog li txo cov tsos mob ntawm peripheral neuropathy hauv cov neeg mob ntshav qab zib.

Kev cai Metabolic:Txawm hais tias nws tsis ncaj qha rau cov ntshav qabzib, cov tshuaj pab glycemic stability los ntawm kev txo qis oxidative kev nyuaj siab thiab sorbitol buildup hauv lub cev.

Kev Tiv Thaiv Microvascular:Epasitide qhia tau hais tias muaj peev xwm tiv thaiv cov kab mob vascular thiab lub raum los ntawm kev txo qis hauv cov ntshav oxidative kev ntxhov siab, pab txo qis ntawm kev mob ntshav qab zib.

Kev nyab xeeb ntawm epacipatid tau raug lees paub meej hauv kev kho mob.

Tej yam tshwm sim:suav nrog cov teeb meem me me hauv plab hnyuv (xws li xeev siab, mob plab, ntuav) thiab nce me ntsis hauv daim siab enzymes (ALT, AST).

Cov tawv nqaij teb:Qee tus neeg mob yuav ua pob liab me ntsis lossis khaus, tshwm sim ntawm qhov tsawg zaus (kwv yees li 1%-3%).

Cov xwm txheej phem heev:Feem ntau tsis tshua muaj tshwm sim ntawm thrombocytopenia lossis kab mob siab tseem ceeb tau raug sau tseg. Cov xwm txheej zoo li no yuav tsum tau txiav tawm sai sai ntawm cov tshuaj thiab kev kho mob ceev

Epalrestat tuaj yeem ua rau muaj kev cuam tshuam tsis zoo hauv qab no thaum siv kho mob, yuav tsum muaj kev sib koom ua ke ntawm cov kws kho mob thiab cov neeg mob:

Reactions ntawm digestive system:Cov teeb meem hauv plab hnyuv muaj xws li xeev siab, ntuav, thiab raws plab me ntsis, uas feem ntau yog cov tsos mob ib ntus.

Cov teebmeem ntawm lub siab ua haujlwm:Ib qho me me ntawm daim siab enzymes tuaj yeem tshwm sim thaum kho, tab sis feem ntau ntawm cov neeg mob tuaj yeem ua haujlwm zoo tom qab txiav cov tshuaj. Kev kuaj xyuas lub siab tsis tu ncua yog qhia.

Hloov cov zis xim:Qee tus neeg mob yuav hnov ​​​​mob liab - cov zis xim av, uas yog ib qho tshwm sim thaum lub sij hawm

Cov neeg thov tsim nyog:

Cov neeg mob ntshav qab zib hom 2 uas muaj HbA1c qib ntawm 7% lossis siab dua thiab txheeb xyuas lossis nce siab -kev pheej hmoo rau peripheral neuropathy.

2) Cov neeg mob hnyav hnyav nrog cov qib insulin siab uas tsis teb zoo rau kev tswj kev noj zaub mov.

3) Cov tib neeg muaj teeb meem microvascular xws li ntshav qab zib nephropathy lossis retinopathy.

Contraindications:

1) Cov neeg uas muaj kev fab tshuaj rau eptifibatide lossis nws cov khoom.

2) Cov neeg uas muaj lub siab ua haujlwm tsis zoo lossis tseem ceeb platelet irregularities.

3) Cov poj niam cev xeeb tub lossis pub niam mis (yuav tsum tau soj ntsuam kom meej).

Eptifibatide zoo txo ​​cov tsos mob neuropathic thiab ua rau qeeb ntawm cov teeb meem hauv cov neeg mob tsim nyog. Rau cov pab pawg uas muaj contraindications, kev ntsuam xyuas zoo lossis kev zam yog qhov tseem ceeb los lav qhov kev nyab xeeb ntawm cov tshuaj.

Ipragiflu tsis tsim nyog rau txhua tus neeg mob ntshav qab zib; nws cov pab pawg npaj suav nrog cov uas twb tau mob ntshav qab zib neuropathy lossis muaj kev pheej hmoo ntawm nws qhov pib. Cov neeg mob pom zoo- tswj cov ntshav qabzib qib thiab tsis muaj cov tsos mob ntawm neuropathy tuaj yeem muaj lawv txoj kev kho mob txaus nrog cov tshuaj hypoglycemic. Qhov kev txiav txim siab siv Ipragiflu yuav tsum tau ua tom qab kev ntsuam xyuas dav dav ntawm tus neeg mob tus mob los ntawm tus kws kho mob kom lav cov tshuaj tsim nyog thiab kev nyab xeeb.

Hauv chaw kho mob, eparasiparib tuaj yeem cuam tshuam nrog lwm cov tshuaj, xav tau cov kws kho mob kom ntsuas tus neeg mob cov phiaj xwm tshuaj.

Cov tshuaj tiv thaiv kab mob ntshav qab zib: Cov ntshav qabzib yuav tsum tau saib xyuas thaum noj nrog metformin lossis sulfonylureas kom tsis txhob muaj ntshav qab zib.

Alpha-glucosidase inhibitors: Siv lawv ua ke tuaj yeem txhim kho tom qab- noj zaub mov tswj ntshav qab zib, yuav tsum tau hloov pauv ntau npaum li cas los tiv thaiv kev pheej hmoo ntawm kev mob ntshav qab zib ntau ntxiv.

Anticoagulants los yog inhibitors ntawm daim siab enzymes: Epasatin tuaj yeem ua rau me ntsis nce qib ntawm daim siab enzymes. Kev ntsuas lub siab ua haujlwm tsis tu ncua yog tsim nyog thaum siv ua ke.

Neuroprotective tshuaj: Zoo li alpha-lipoic acid los yog bepridil sodium. Cov kev tshawb fawb soj ntsuam tam sim no qhia tau hais tias kev kho mob ua ke yuav tsis tuaj yeem txhim kho kev ua tau zoo thiab tuaj yeem ua rau muaj kev phiv tsis zoo. Ceev faj thaum siv.

Los ntawm peb qhov kev ntsuam xyuas ntawm kaum nqe lus nug saum toj no, peb tau nkag siab tob txog cov txiaj ntsig zoo ntawm eplastin tiag tiag muab rau cov neeg mob ntshav qab zib. Hauv kev kho mob tiag tiag, nws yog qhov tseem ceeb kom ua raws li cov lus qhia kho mob nruj me ntsis. Kev ua raws li cov cai tau teev tseg yog qhov kev tiv thaiv zoo tshaj plaws los ua kom muaj txiaj ntsig zoo tshaj plaws thiab kev nyab xeeb.

Cov ntaub ntawv

⒈ Hasegawa, G., & Yamada, Y. (2017).Epalrestatinhibits ntshav qab zib neuropathy: soj ntsuam thiab sim pov thawj. Phau ntawv Journal of Diabetes Investigation.https://onlinelibrary.wiley.com/

⒉Ishikawa, T., & Yoshida, K. (2015). Kev ua tau zoo ntawm Epalrestat hauv cov neeg mob ntshav qab zib peripheral neuropathy. Kev tshawb nrhiav ntshav qab zib thiab kev xyaum ua haujlwm kho mob.

https://www.sciencedirect.com/journal/diabetes-kev tshawb fawb-thiab- kho mob- xyaum

⒊American Diabetes Association. (2020). Cov qauv kev kho mob hauv ntshav qab zib. Mob Ntshav Qab Zib.https://diabetesjournals.org/care

⒋National Institute for Health and Care Excellence (NICE) cov lus qhia rau kev tswj cov ntshav qab zib hom 2.https://www.nice.org.uk/guidance/ng28

⒌International Diabetes Federation (IDF). (2021). IDF Diabetes Atlas, 9th edition.https://idf.org/