Urolithin A: Mitophagy Flux thiab B2B Qib Specifications
Apr 05, 2026
Tso lus
Puas yog Urolithin A daws qhov "Tsis yog-Tshuaj" microbiome bottleneck?
Qhov kev muaj tiag ntawm kev noj pomegranate yog kev ntxhov siab: kwv yees li 60% ntawm tib neeg tsis muaj lub plab tshwj xeeb (Gordonibacter) uas yuav tsum tau ua los ntawm Uolithin A los ntawm ellagitannins. Rau ib hom B2B, qhov no yog qhov "Tsis yog-Tus tsim khoom" qhov sib txawv. Peb tsis yog pitching lwm antioxidant; Peb tab tom muab cov metabolic bypass.
Los ntawm kev muab 98% HPLC-ntshiab ncaj qha metabolite, peb tshem tawm qhov sib txawv ntawm plab microbiome ntau haiv neeg. Cov txheej txheem tam sim no tuaj yeem lav qhov tseeb, bioavailable mitophagy trigger - xaiv tshem tawm ntawm mitochondria dysfunctional mitochondria -txawm qhov kawg - cov neeg siv lub sab hauv microbial toj roob hauv pes. Nws yog molecular precision, tsis noj kev cia siab.
Vim li cas cov residual catalysts cuam tshuam rau Urolithin A txee -lub neej?
A 98.0% CoA (Certificate of Analysis) feem ntau yog lub npog ntsej muag. Hauv kev sib xyaw ntawm Urolithin A, qhov kev txhawj xeeb tiag tiag tsis yog 98% purity, tab sis cov toxicological profile ntawm qhov seem 2%. Ntawm Xi'an Tihealth, peb tsom mus rau "Invisible Impurities"-tshwj xeeb residual Palladium (Pd) thiab Copper (Cu) los ntawm theem coupling. Cov kab hlau no, yog tias sab laug siab dua 10ppm, ua raws li pro-oxidants nyob rau hauv qhov kawg formulation, degrading lwm yam actives nyob rau hauv lub blend.
Tsis tas li ntawd, peb saib xyuas "Polymorphic Crystalline Phase." Yog tias cov iav siv lead ua tsis ruaj khov thaum lub sijhawm ziab, cov hmoov yuav clump thiab poob flowability nyob rau hauv siab - ceev encapsulation kab. Yog tias koj tus neeg muag khoom tsis tham txog kev ruaj ntseg polymorphic, lawv tsis muab API - cov ntaub ntawv qib.
Puas yog D90 micronization yog khoom kim heev lossis tsim nyog tsim nyog?
Urolithin A yog "cib plua plav" zoo nyob rau hauv nws lub xeev raw-lipophilic heev thiab tawv ncauj insoluble. High purity tsis cuam tshuam yog tias cov khoom dhau los ntawm GI ib puag ncig unabsorbed. Qhov no yog qhov uas particle engineering dictates efficiency.
Peb tau txav dhau tus qauv milling rau Supercritical Jet Micronization, tsom mus rau D90 < 10 μm kev faib tawm. Qhov no tsis yog kev lag luam gimmick; nws nce qhov chaw zoo ntawm thaj tsam ze li ntawm 400%, yuam kom qhov tawg ntawm cov hnyuv loj. Rau kev noj qab haus huv noj qab haus huv zoo, qhov micronization no yog tib txoj hauv kev los xyuas kom meej tias cov active muaj sia nyob thawj zaug - dhau cov metabolism thiab mus txog lub cev.
Urolithin A Technical Data Sheet (TDS)
|
Technical Parameters |
Specification (Pharma / Kev Tshawb Fawb Qib) |
Txoj Kev Xeem |
|
IUPAC npe |
3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-ib |
-- |
|
Qhov tshwm sim |
Fine Off-White Crystalline Powder |
Pom kev |
|
Kev Ntsuas (Purity) |
Ntau dua lossis sib npaug li 98.0% |
HPLC (Internal Method SOP-UA-05) |
|
Kev txheeb xyuas |
Sib raug rau Reference Standard |
1H-NMR / LC-MS |
|
Particle Loj (D90) |
Tsawg dua los yog sib npaug li 10 μm |
Laser Diffraction (Malvern 3000) |
|
Heavy Metals (Pb) |
Tsawg dua lossis sib npaug li 10 ppm |
ICP-MS |
|
Residual Solvents |
Ethanol Tsawg dua lossis sib npaug li 5000ppm; Methanol Tsawg dua los yog sib npaug rau 3000ppm |
GC-Hloov chaw |
|
Poob rau ziab |
Tsawg dua lossis sib npaug li 1.0% |
Lub tshuab nqus tsev qhov cub (105 degree, 3h) |
Cov ntaub ntawv
-
Cell Metabolism:Urolithin A induces mitophagy thiab prolongs lifespan.https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30251-2
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Nature Medicine:Lub mitophagy activator urolithin A muaj kev nyab xeeb rau tib neeg.https://www.nature.com/articles/s41591-019-0473-2
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JAMA Network Qhib:Urolithin Ib qho ntxiv rau cov leeg mob.Tsab ntawv xov xwm no tshwm sim thawj zaug https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788244
FAQ Tshooj
Q: Vim li cas cov xim batch sib txawv ntawm -dawb mus rau daj daj?
A:Cov me me chromatic hloov pauv yog muaj nyob rau hauv siab -purity polyphenolic metabolites. Qhov no feem ntau yog khi rau cov kinetics qhuav thiab qhov tshwm sim crystalline polymorph. Ntev npaum li qhov HPLC qhov kev ntsuam xyuas pom zoo ntau dua lossis sib npaug rau 98.0%, cov kev hloov kho kom zoo nkauj no tsis muaj kev cuam tshuam rau mitophagy-inducing potency.
Q: Puas yog Xi'an Tihealth's Urolithin A haum rau lipid-raws li softgels?
A:kiag li. Muab nws lipophilic profile, Urolithin A yog qhov zoo tshaj plaws tsim nrog MCT roj lossis lecithin. Peb micronized D10 / D50 / D90 tswj xyuas kom cov khoom nyob twj ywm hauv kev ncua, tiv thaiv "slugging" los yog sedimentation thaum lub sij hawm softgel filling txheej txheem.
Q: Koj tswj tau li cas rau residual synthesis intermediates?
A:Peb ua tiav -spectrum LC-MS ntawm txhua pawg. Peb tshwj xeeb taug qab "marker impurities" xws li resorcinol thiab 2-bromo-5-hydroxybenzoic acid. Peb ua raws li ICH Q3A cov lus qhia kom ntseeg tau tias cov neeg nruab nrab no tau zoo hauv qab qhov kev xav tau rau cov tshuaj intermediates.
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