Cia peb daws qhov N-Acetyl L-Tyrosine (NALT) piv rau tus qauv L-Tyrosine debate. Nws yog qhov feem ntau nkag siab yuam kev kinetic kev lag luam hauv kev lag luam nootropics. Formulators nyeem ib qho kev lag luam blog, saib cov kab lus "NALT muaj ntau dua bioavailable," thiab dig muag cov khoom acetylated variant rau hauv cov tshuaj ntsiav qhuav. Qhov ntawd yog qhov yuam kev biochemical loj heev.

NtawmXi'an Tihealth (Xi'an Tihealth Biotechnology Co., Ltd.), peb muab ob APIs rau lub ntiaj teb no ntxiv hom. Peb tsis ua si nyiam. Peb phim lub molecule rau lub matrix. Cov lus qhia kev qhia no ua rau muaj kev txwv tsis pub muaj kev txwv hnyav ntawm tus qauv Tyrosine, qhov zais zais ntawm lub raj mis ntawm NALT deacetylation, thiab cov cai tsis muaj kev cuam tshuam rau kev xaiv qhov tseeb catecholamine precursor rau RTDs piv rau cov khoom- koob tshuaj.

Yog tias koj tab tom tsim cov tshuaj tua hluav taws xob ua kua lossis dej haus kom pom tseeb, tus qauv L-Tyrosine tsis siv neeg kho tshuab. Saib ntawm qhov kev muaj tiag thermodynamic. Ntshiab L-Tyrosine muaj abysmal aqueous solubility txwv ntawm kwv yees li 0.45 grams ib liter ntawm 25℃. Koj tsis tuaj yeem yuam kev kho mob 1,000mg koob tshuaj rau hauv 2-ounce kua tshuaj. Nws yuav instantly precipitate, tig koj cov dej haus hwm rau hauv lub raj mis ntawm chalky sludge.

Ntawm no, NALT yog tus huab tais uas tsis muaj kev sib cav. Los ntawm kev txuas ib pawg acetyl rau cov amine, cov molecular polarity hloov ua nruj ua tsiv. Solubility skyrockets. Koj tuaj yeem yooj yim yaj cov khoom loj ntawm NALT rau hauv dej txias yam tsis muaj ib qho siv lead ua poob tawm ntawm kev daws. RauNpaj-To-Drink (RTD) formulations, kev sib cav lawm. Koj them tus nqi them rau NALT, lossis koj tso cov kua hom ntawv tag nrho.

Tab sis yuav ua li cas yog tias koj ntim cov tshuaj ntsiav qhuav? Cov dej solubility tsis cuam tshuam rau hauv cov tshuaj ntsiav. Qhov no yog qhov uas cov formulators ua yuam kev kim. Lawv xav tias NALT cov dej solubility zoo dua txhais tau rau lub hlwb dopamine synthesis. Clinical pharmacokinetics ua pov thawj lwm yam.

NALT nws tus kheej tsis hloov ncaj qha rau hauv L-DOPA. Koj lub cev yuav tsum ua ntejdeacetylatenws- tshem tawm cov acetyl pawg tawm ntawm cov enzymes hauv lub raum thiab daim siab- kom tawm tau dawb L-Tyrosine. Cov kev tshawb fawb hauv cov hlab ntsha thiab qhov ncauj qhia tau hais tias qhov kev sib cais ntawm cov enzymatic no tsis muaj txiaj ntsig zoo. Ib feem pua ​​​​ntawm cov NALT uas tau noj yog tsuas yog tawm hauv cov zis ua ntej lub cev tuaj yeem hloov pauv. Yog li, milligram rau milligram,tus qauv L-Tyrosine muab qhov zoo tshaj plaws, tam sim ntawd catecholamine spikepiv rau NALT. Yog tias koj tab tom muab cov hmoov qhuav los yog ntim cov tshuaj ntsiav, tus qauv L-Tyrosine yog pheej yig dua, ncaj qha, thiab kho kom zoo dua.

Tshawb xyuas koj daim ntawv noj tshuaj. Xi'an Tihealth muab tshuaj -qib (Ntau dua lossis sib npaug rau 99.0% HPLC) cov lus qhia tshwj xeeb rau cov amino acids. Teem koj qhov kev yuav khoom nrog koj lub tsheb:

Ua raws li koj qhov kev txiav txim siab R & D ntawm kev kho mob kinetics, tsis yog kev lag luam thov:

• Metabolism: N-acetyl-L-tyrosine thiab N-acetyl-L-cysteine ​​li tyrosine thiab cysteine ​​precursors thaum lub sij hawm intravenous infusion hauv tib neeg.(Cov kev tshawb fawb tseeb ua pov thawj qhov tsis muaj txiaj ntsig deacetylation thiab kev tso zis siab ntawm NALT).
  URL:https://pubmed.ncbi.nlm.nih.gov/2772624/
• Phau ntawv Journal of Psychiatric Research: Kev coj cwj pwm thiab kev txawj ntse ntawm kev noj tyrosine hauv cov neeg laus noj qab haus huv.(Kev lees paub ntawm tus qauv L-Tyrosine qhov kev ua tau zoo ntawm kev paub txog kev ntxhov siab).
  URL:https://pubmed.ncbi.nlm.nih.gov/26424423/

Cov placebo, ua ke nrog cov kua dej sai sai. Vim tias NALT feem ntau yog tsim nyob rau hauv cov kua tshuaj txhaj tshuaj (feem ntau ua ke nrog hnyav caffeine), lub plab zom mov yog exponentially sai dua li gelatin capsule ntawm L-Tyrosine. Cov kua hom xa cov payload mus rau txoj hnyuv tam sim ntawd. Qhov pom tau tias "ceev" yog kev ua haujlwm ntawm lub tsheb ua kua, tsis yog lub molecule nws tus kheej.

Q: Kuv puas tuaj yeem siv ob qho L-Tyrosine thiab NALT hauv tib lub hmoov ua ntej- workout hmoov?

Koj muaj peev xwm, tab sis nws yog chemically redundant. Yog tias nws yog cov hmoov qhuav uas tus neeg siv sib xyaw nrog dej, tus qauv L-Tyrosine yuav tawm me ntsis grit rau hauv qab ntawm shaker, tab sis nws yuav xa cov catecholamine synthesis zoo dua. Ntxiv NALT tsuas yog nce koj cov nqi khoom siv raw (COGS) yam tsis tau ntxiv cov txiaj ntsig ntawm lub cev rau kev sib xyaw qhuav.

Q: Xi'an Tihealth ua li cas thiaj li ua kom huv si ntawm nws cov Tyrosine derivatives?

Txawm hais tias koj tau txais peb cov khoom lag luam L-Tyrosine lossis peb cov acetylated NALT, peb tswj hwm HPLC kev siv tau nruj (Ntau dua lossis sib npaug rau 99.0%). Tsis tas li ntawd, peb siv polarimetry los lav qhov tshwj xeeb (+)- kho qhov muag rotation, xyuas kom koj tau txais cov tshuaj lom neeg lom neeg L-isomer, tsis yog cov khoom sib xyaw ua ke.

Txoj Kev Txiav Txim Siab: Tsheb Dictates Procurement

Tsis txhob them tus nqi hwm rau acetylated amino acids yog tias koj tsuas yog sau cov tshuaj ntsiav. Txhob rhuav tshem koj cov dej haus RTD nrog insoluble puag amino acids. Lub tsheb dictates lub molecule. Nkag siab txog deacetylation bottleneck. hwm cov thermodynamics.

Npaj los muab qhov tseeb API rau koj daim ntawv noj tshuaj tshwj xeeb? Hu rau Xi'an Tihealth pab pawg kws tshaj lij hnub no kom ruaj ntseg tshuaj -qib NALT lossis L-Tyrosine.